Non-Avian Animal Reservoirs Present a Source of Influenza A PB1-F2 Proteins with Novel Virulence-Enhancing Markers
Identifieur interne : 000037 ( 1968/Analysis ); précédent : 000036; suivant : 000038Non-Avian Animal Reservoirs Present a Source of Influenza A PB1-F2 Proteins with Novel Virulence-Enhancing Markers
Auteurs : Irina V. Alymova [États-Unis] ; Ian A. York [États-Unis] ; Jonathan A. Mccullers [États-Unis]Source :
- PLoS ONE [ 1932-6203 ] ; 2014.
Descripteurs français
- KwdFr :
- Animaux, Chiens (sang), Chiens (virologie), Equus caballus (sang), Equus caballus (virologie), Grippe humaine (transmission), Grippe humaine (virologie), Humains, Infections à Orthomyxoviridae (immunologie), Infections à Orthomyxoviridae (sang), Infections à Orthomyxoviridae (virologie), Phylogénie, Protéines virales (), Protéines virales (génétique), Protéines virales (immunologie), Suidae (sang), Suidae (virologie), Virus de la grippe A (génétique), Virus de la grippe A (immunologie), Virus de la grippe A (isolement et purification), Virus de la grippe A (pathogénicité).
- MESH :
- génétique : Protéines virales, Virus de la grippe A.
- immunologie : Infections à Orthomyxoviridae, Protéines virales, Virus de la grippe A.
- isolement et purification : Virus de la grippe A.
- pathogénicité : Virus de la grippe A.
- sang : Chiens, Equus caballus, Infections à Orthomyxoviridae, Suidae.
- virologie : Chiens, Equus caballus, Grippe humaine, Infections à Orthomyxoviridae, Suidae.
- Animaux, Grippe humaine, Humains, Phylogénie, Protéines virales.
English descriptors
- KwdEn :
- Animals, Dogs (blood), Dogs (virology), Horses (blood), Horses (virology), Humans, Influenza A virus (genetics), Influenza A virus (immunology), Influenza A virus (isolation & purification), Influenza A virus (pathogenicity), Influenza, Human (transmission), Influenza, Human (virology), Orthomyxoviridae Infections (blood), Orthomyxoviridae Infections (immunology), Orthomyxoviridae Infections (virology), Phylogeny, Swine (blood), Swine (virology), Viral Proteins (chemistry), Viral Proteins (genetics), Viral Proteins (immunology).
- MESH :
- chemical , chemistry : Viral Proteins.
- blood : Dogs, Horses, Orthomyxoviridae Infections, Swine.
- genetics : Influenza A virus, Viral Proteins.
- immunology : Influenza A virus, Orthomyxoviridae Infections, Viral Proteins.
- isolation & purification : Influenza A virus.
- pathogenicity : Influenza A virus.
- transmission : Influenza, Human.
- virology : Dogs, Horses, Influenza, Human, Orthomyxoviridae Infections, Swine.
- Animals, Humans, Phylogeny.
Abstract
PB1-F2 protein, expressed from an alternative reading frame of most influenza A virus (IAV) PB1 segments, may possess specific residues associated with enhanced inflammation (L62, R75, R79, and L82) and cytotoxicity (I68, L69, and V70). These residues were shown to increase the pathogenicity of primary viral and secondary bacterial infections in a mouse model. In contrast to human seasonal influenza strains, virulence-associated residues are present in PB1-F2 proteins from pandemic H1N1 1918, H2N2 1957, and H3N2 1968, and highly pathogenic H5N1 strains, suggesting their contribution to viruses' pathogenic phenotypes. Non-human influenza strains may act as donors of virulent PB1-F2 proteins. Previously, avian influenza strains were identified as a potential source of inflammatory, but not cytotoxic, PB1-F2 residues. Here, we analyze the frequency of virulence-associated residues in PB1-F2 sequences from IAVs circulating in mammalian species in close contact with humans: pigs, horses, and dogs. All four inflammatory residues were found in PB1-F2 proteins from these viruses. Among cytotoxic residues, I68 was the most common and was especially prevalent in equine and canine IAVs. Historically, PB1-F2 from equine (about 75%) and canine (about 20%) IAVs were most likely to have combinations of the highest numbers of residues associated with inflammation and cytotoxicity, compared to about 7% of swine IAVs. Our analyses show that, in addition to birds, pigs, horses, and dogs are potentially important sources of pathogenic PB1-F2 variants. There is a need for surveillance of IAVs with genetic markers of virulence that may be emerging from these reservoirs in order to improve pandemic preparedness and response.
Url:
DOI: 10.1371/journal.pone.0111603
PubMed: 25368997
PubMed Central: 4219726
Affiliations:
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PMC:4219726Le document en format XML
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These residues were shown to increase the pathogenicity of primary viral and secondary bacterial infections in a mouse model. In contrast to human seasonal influenza strains, virulence-associated residues are present in PB1-F2 proteins from pandemic H1N1 1918, H2N2 1957, and H3N2 1968, and highly pathogenic H5N1 strains, suggesting their contribution to viruses' pathogenic phenotypes. Non-human influenza strains may act as donors of virulent PB1-F2 proteins. Previously, avian influenza strains were identified as a potential source of inflammatory, but not cytotoxic, PB1-F2 residues. Here, we analyze the frequency of virulence-associated residues in PB1-F2 sequences from IAVs circulating in mammalian species in close contact with humans: pigs, horses, and dogs. All four inflammatory residues were found in PB1-F2 proteins from these viruses. Among cytotoxic residues, I68 was the most common and was especially prevalent in equine and canine IAVs. Historically, PB1-F2 from equine (about 75%) and canine (about 20%) IAVs were most likely to have combinations of the highest numbers of residues associated with inflammation and cytotoxicity, compared to about 7% of swine IAVs. Our analyses show that, in addition to birds, pigs, horses, and dogs are potentially important sources of pathogenic PB1-F2 variants. There is a need for surveillance of IAVs with genetic markers of virulence that may be emerging from these reservoirs in order to improve pandemic preparedness and response.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Class, Ec" uniqKey="Class E">EC Class</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author><author><name sortKey="Van Beek, R" uniqKey="Van Beek R">R Van Beek</name></author><author><name sortKey="De Jong, Jc" uniqKey="De Jong J">JC De Jong</name></author><author><name sortKey="Rimmelzwaan, Gf" uniqKey="Rimmelzwaan G">GF Rimmelzwaan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author><author><name sortKey="Schneeberger, Pm" uniqKey="Schneeberger P">PM Schneeberger</name></author><author><name sortKey="Rozendaal, Fw" uniqKey="Rozendaal F">FW 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K" uniqKey="Zhang K">K Zhang</name></author><author><name sortKey="Mccullers, Ja" uniqKey="Mccullers J">JA McCullers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smith, Am" uniqKey="Smith A">AM Smith</name></author><author><name sortKey="Adler, Fr" uniqKey="Adler F">FR Adler</name></author><author><name sortKey="Mcauley, Il" uniqKey="Mcauley I">IL McAuley</name></author><author><name sortKey="Gutenkunst, Rn" uniqKey="Gutenkunst R">RN Gutenkunst</name></author><author><name sortKey="Ribeiro, Rm" uniqKey="Ribeiro R">RM Ribeiro</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Iverson, Ar" uniqKey="Iverson A">AR Iverson</name></author><author><name sortKey="Boyd, Kl" uniqKey="Boyd K">KL Boyd</name></author><author><name sortKey="Mcauley, Jl" uniqKey="Mcauley J">JL McAuley</name></author><author><name sortKey="Plano, Lr" uniqKey="Plano L">LR Plano</name></author><author><name sortKey="Hart, Me" uniqKey="Hart M">ME Hart</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li><li>Tennessee</li></region></list><tree><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Alymova, Irina V" sort="Alymova, Irina V" uniqKey="Alymova I" first="Irina V." last="Alymova">Irina V. Alymova</name></region><name sortKey="Alymova, Irina V" sort="Alymova, Irina V" uniqKey="Alymova I" first="Irina V." last="Alymova">Irina V. Alymova</name><name sortKey="Mccullers, Jonathan A" sort="Mccullers, Jonathan A" uniqKey="Mccullers J" first="Jonathan A." last="Mccullers">Jonathan A. Mccullers</name><name sortKey="Mccullers, Jonathan A" sort="Mccullers, Jonathan A" uniqKey="Mccullers J" first="Jonathan A." last="Mccullers">Jonathan A. Mccullers</name><name sortKey="York, Ian A" sort="York, Ian A" uniqKey="York I" first="Ian A." last="York">Ian A. York</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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